My 02 R6 has 48,400 on it right now, and it still runs like a top. Like natedogg said, if you take care of the motor it shoud last you a while. The only things that have failed on my bike were the generator cover gasket, and the clutch cover gasket. Both of them happened within about 2000 miles of each other. Other than than it's just been normal stuff: tires, chains, plugs, filters, coolant change.